Custom Synthesis

Tosoh is positioned with business units that specialize in fluorination, bromination and iodination to leverage their expertise in in the custom chemical field. 


In addition, Tosoh’s expertise in other areas such as catalyst technology and coupling reactions are compelling reasons to consider Tosoh for your custom synthesis projects. Tosoh offers a full range of custom synthesis to support active pharmaceutical development as well as non GMP capabilities. Fifty highly skilled R&D scientists are ready to assist with synthesis route scouting, selection and process development. Coupled with our large analytical staff, we have the critical mass to progress your project seamlessly from process development through pilot plant right into commercial-scale manufacturing.

Key Technologies:

Direct Fluorination
Electrophilic Fluorination
Nucleophilic Fluorination
HF Addition (Solution and Gaseous)
Bromination (Including our proprietary isomer control technology)
HBr Addition (Markovnikov and Anti-Markovnikov)
Iodination (Including both Electrophilic and Nucleophilic Iodination)
Aryl Amination
Coupling technologies both with and without heavy metal catalysis
Organometallic Reactions